pentobarbital will lower the level or influence of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will decrease the level or effect of budesonide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
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Barbiturates can induce hepatic microsomal enzymes causing enhanced metabolism and decreased anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); patients stabilized on anticoagulant therapy could need dosage adjustments if barbiturates are additional to or withdrawn from their dosage routine
Observe Carefully (1)pentobarbital will reduce the extent or effect of mestranol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Caution when discontinuing CYP3A4 inducers which might be coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone could boost and can lead to likely deadly respiratory despair.
pentobarbital decreases levels of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration with strong CYP3A4 inducers; these medication decrease publicity to vandetanib by as many as 40%.
pentobarbital boosts consequences of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Warning/Check. Coadministration of ifosfamide get more info with CYP2B6 inducers might enhance metabolism of ifosfamide to its metabolite. Keep an eye on for elevated results/toxicities if coupled with CYP2B6 inducers.
pentobarbital will lower the level or influence of triamcinolone acetonide injectable suspension by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will reduce the extent or impact of hydrocortisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will decrease the extent or result of paclitaxel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.
Keep an eye on Carefully (one)pentobarbital will lessen the extent or influence of levamlodipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lower the level or impact of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Strong or average CYP3A4 inducers may increase rate of diazepam elimination; consequently, efficacy of diazepam could be reduced.
pentobarbital will decrease the level or impact of quinidine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.